HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666093Generated: October 30, 2026
Diisopropylethylamine → 3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-5-nitro-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide
https://huagongshe.com/reaction/1666093
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Amino-N,4-dimethylbenzamide | HCID 12607973 | — |
| Reactant | (6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine | HCID 58928507 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-5-nitro-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide | HCID 10200165 | 80.2% |
Reaction Steps
(6-Chloro-5-nitro-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-methyl-amine (1.0 mmol) was dissolved in p-dioxane (2 mL), and 3-amino-4,N-dimethyl-benzamide (0.2 g, 1.2 mmol) and DIEA (0.3 mL) were added. The resulting mixture was heated to 80° C. for overnight. The product (0.31 g, yield 80%) was purified by column silica gel chromatography. MS (m/z): 387 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044040B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-f0d792a4a7884adf93400e68b3b38a79 |
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| Source note | uspto-grants-2011_10 |
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