4-Methoxy-2,3-dihydrobenzofuran-3-amine → HCID 178488328, compound

HRID 1666105Notes

Reaction equation

HRID 1666105 reaction equation
C([Si]([O:8][CH2:9][C:10]1[C:15]([N+:16]([O-])=O)=[CH:14][CH:13]=[CH:12][C:11]=1[N:19]=[C:20]=S)(C)C)(C)(C)C.[CH3:22][O:23][C:24]1[C:29]2[CH:30]([NH2:33])[CH2:31][O:32][C:28]=2[CH:27]=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[C:29]2[CH:30]([NH:33][C:20]3[O:8][CH2:9][C:10]4[C:15]([NH2:16])=[CH:14][CH:13]=[CH:12][C:11]=4[N:19]=3)[CH2:31][O:32][C:28]=2[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 672125224-Methoxy-2,3-dihydrobenzofuran-3-amineHCID 86639788Tert-butyl-(2-isothiocyanato-6-nitro-benzyloxy)-dimethyl-silane2×

Product 1

HCID 178488328HCID 178488328, compound

Procedure

The title compound, MS (ISP) m/e=312.0 [(M+H)+], was prepared from tert-butyl-(2-isothiocyanato-6-nitro-benzyloxy)-dimethyl-silane (intermediate 2) and 4-methoxy-2,3-dihydro-benzofuran-3-ylamine according to the procedure described for example 1 and 2.

Sources & evidence

ORD record
ord-0d4173c8838a4e5a8978c217e1570fd8
Source dataset
uspto-grants-2011_10
Patent number
US08044047B2

Reaction notes

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