Cyclopropanesulfonyl chloride → N-[2-[[(1R)-2,3-dihydro-1H-inden-1-yl]amino]-4H-3,1-benzoxazin-5-yl]cyclopropanesulfonamide

HRID 1666109Notes

Reaction equation

HRID 1666109 reaction equation
[C@H:1]1([NH:10][C:11]2[O:12][CH2:13][C:14]3[C:20]([NH2:21])=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH:22]1([S:25](Cl)(=[O:27])=[O:26])[CH2:24][CH2:23]1>>[C@H:1]1([NH:10][C:11]2[O:12][CH2:13][C:14]3[C:20]([NH:21][S:25]([CH:22]4[CH2:24][CH2:23]4)(=[O:27])=[O:26])=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2760919Cyclopropanesulfonyl chlorideHCID 178507384HCID 178507384, compound

Product 1

HCID 178527467N-[2-[[(1R)-2,3-dihydro-1H-inden-1-yl]amino]-4H-3,1-benzoxazin-5-yl]cyclopropanesulfonamide

Procedure

The title compound, MS (ISP) m/e=384.1 [(M+H)+], was prepared from (R)—N2-indan-1-yl-4H-benzo[d][1,3]oxazine-2,5-diamine (example 2) and cyclopropylsulfonyl chloride according to the procedure described for example 5.

Sources & evidence

ORD record
ord-1f96c274908a46a5b076e9fbbc84a7f1
Source dataset
uspto-grants-2011_10
Patent number
US08044047B2

Reaction notes

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