Methanesulfonyl chloride → N-[2-[[(1R)-2,3-dihydro-1H-inden-1-yl]amino]-4H-3,1-benzoxazin-5-yl]methanesulfonamide

HRID 1666110Notes

Reaction equation

[C@H:1]1([NH:10][C:11]2[O:12][CH2:13][C:14]3[C:20]([NH2:21])=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>>[C@H:1]1([NH:10][C:11]2[O:12][CH2:13][C:14]3[C:20]([NH:21][S:23]([CH3:22])(=[O:25])=[O:24])=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178507384HCID 178507384, compound

Product 1

HCID 178504994N-[2-[[(1R)-2,3-dihydro-1H-inden-1-yl]amino]-4H-3,1-benzoxazin-5-yl]methanesulfonamide

Procedure

The title compound, MS (ISP) m/e=358.0 [(M+H)+], was prepared from (R)—N2-indan-1-yl-4H-benzo[d][1,3]oxazine-2,5-diamine (example 2) and methanesulfonyl chloride according to the procedure described for example 5.

Sources & evidence

ORD record: ord-02fad308c617416b8348ef4bc4e4126a
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08044047B2

Reaction notes

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