HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 1-(3,5-Difluorophenyl)-2-methylpropan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 3,5-Difluorobenzyl bromide | HCID 518896 | — |
| Product | 1-(3,5-Difluorophenyl)-2-methylpropan-2-ol | HCID 22063495 | — |
Reaction Steps
The target compound is obtained by reacting a Grignard compound, prepared from 25.0 g (121 mmol) of 3,5-difluorobenzyl bromide, with 12.6 mL (171 mmol) of acetone. Yellow oil. Yield: 13.5 g (60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044046B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-f524d86d9b1442c9819429dc4c2b69c6 |
| Source note | uspto-grants-2011_10 |