HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-benzyloxy-8-{2-[2-(3,5-difluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 22063456 | HCID 22063456 | — |
| Reactant | 1-(3,5-Difluorophenyl)-2-methylpropan-2-amine | HCID 22063501 | — |
| Product | 6-benzyloxy-8-{2-[2-(3,5-difluorophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-4H-benzo[1,4]oxazin-3-one | HCID 22063475 | — |
Reaction Steps
Prepared from 1.73 g (4.84 mmol) of benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one and 0.80 g (4.32 mmol) of 2-(3,5-difluorophenyl)-1,1-dimethylethylamine in the usual way. Yield: 1.50 g (58%, hydrochloride); melting point: 240° C.-244° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044046B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-7602d1fe7e69450f84646048eb65584c |
| Source note | uspto-grants-2011_10 |