HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-benzyloxy-8-{2-[2-(3,5-dimethylphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 22063456 | HCID 22063456 | — |
| Reactant | HCID 22063466 | HCID 22063466 | — |
| Product | 6-benzyloxy-8-{2-[2-(3,5-dimethylphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-4H-benzo[1,4]oxazin-3-one | HCID 22063449 | — |
Reaction Steps
Prepared analogously to the method for Example 8(d) from 1.47 g (4.1 mmol) of benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one and 0.65 g (3.7 mmol) of 2-(3,5-dimethylphenyl)-1,1-dimethylethylamine. Yield: 1.1 g (51%, hydrochloride); melting point: 220° C.-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044046B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4e41ccfb0d5946bea4d02f6f5b7172d1 |
| Source note | uspto-grants-2011_10 |