Water → HCID 59803699, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-(3,4-dimethoxyphenyl)propynoic acid (6-amino-1-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl) amide (2.27 g, 6.3 mmol) in 12 ml of dry dimethylformamide was added phosphorous pentaoxyde (5 g, 17 mmol). The mixture was stirred at 100° C. for 10 min and cooled to room temperature. The product was recipitated by adding water (100 ml), filtered under reduced pressure, washed thoroughly with water and dryed at 70° C., light yellow yielding 8-(3,4-dimethoxyphenylethynyl)-3-ethyl-3,7-dihydro-purine-2,6-dione (1.6 g, 74%).

Provenance & Evidence