HCID 21958820, compound → HCID 59803724, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-amino-1-ethyl-3-propargyluracil (5 g, 26 mmol) in 75 ml of 50% acetic acid was heated at 50-60° C. Subsequently sodium nitrite (2.5 g, 36 mmol) was added in small portions over a period of 5 min. The end of the reaction was indicated by the formation of brown nitric gases. The deep violet solution was highly concentrated under reduced pressure. The remaining violet crystals were was suspended in a minimum of water, cooled to 4° C., filtered under reduced pressure, washed with methanol and dried at 70° C. Yield: 5 g (87%).

Provenance & Evidence