Phosphorus oxychloride → 4-Chloro-6,7-dimethoxyquinazoline

Participants

Reaction Conditions

Reaction Steps

In a 100 mL flask equipped with a reflux condenser, 6,7-dimethoxy-quinazolin-4-one 4.5 g (20 mmol), phosphoryl chloride (45 ml) were added. The mixture was stirred at 105° C. for 2 h, and then was poured into 100 mL of ice water carefully, and off-white squama solid was deposited slowly, which was filtered, dried and identified as the title compound. Yield: 80%.

Provenance & Evidence