Formamide → HCID 12413924, compound

HRID 1666238Notes

Reaction equation

HRID 1666238 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=O)=[C:4]([NH2:11])[CH:3]=1.[CH:12]([NH2:14])=[O:13]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([CH:6]=[N:14][C:12](=[O:13])[NH:11]2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 666462-Amino-4-chlorobenzoic acid

Product 1

HCID 12413924HCID 12413924, compound

Procedure

4-chloro-2-amino-benzoic acid (10.0 g) was dissolved into 50 mL of formamide, the mixture was reacted under reflux for 5 h. A lot of solid was deposited, which was filtered and dried to obtain 1.5 g of 7-chloro-quinazolone.

Workup

  1. customthe mixture was reacted
  2. temperatureunder reflux for 5 h
  3. filtrationwhich was filtered
  4. customdried

Sources & evidence

ORD record
ord-deb99632304f446089a08e9b82edbb55
Source dataset
uspto-grants-2011_10
Patent number
US08044063B2

Reaction notes

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