HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666271Generated: October 30, 2026
Potassium Hydroxide → 8-ethyl-6-(1H-imidazol-5-yl)-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine
https://huagongshe.com/reaction/1666271
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-(1H-imidazol-5-yl)acetonitrile | HCID 571973 | — |
| Reactant | 1,1-Dimethylethyl 2-[8-ethyl-2-(ethylamino)-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-1H-pyrrole-1-carboxylate | HCID 16124360 | — |
| Reactant | 4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde | HCID 57606953 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-ethyl-6-(1H-imidazol-5-yl)-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine | HCID 57606968 | — |
Reaction Steps
A solution of potassium hydroxide (0.139 g, 2.48 mmol) in absolute ethanol (3.0 mL) was added to a pressure tube charged with 4-(ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde (0.229 g, 1.08 mmol), prepared using procedures similar to those described for Intermediate 1, and 2-(1H-imidazol-5-yl)acetonitrile (0.174 g, 162 mmol) and heated to 70° C. After 12 h, the reaction was allowed to cool to room temperature and concentrated in vacuo affording 8-ethyl-6-(1H-imidazol-5-yl)-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine as a solid. The product was used in the subsequent step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08044062B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-be032dab5c4644bf889b9feee44a728b |
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| Source note | uspto-grants-2011_10 |
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