Ethanol → Ethyl 2-(2,4-difluorophenyl)pyridine-3-carboxylate

HRID 166628Notes

Reaction equation

HRID 166628 reaction equation
[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[CH3:37][CH2:38][OH:39].[Cl:7][c:8]1[c:9]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[cH:15][cH:16][cH:17][n:18]1.[F:19][c:20]1[c:21]([B:27]([OH:28])[OH:29])[cH:22][cH:23][c:24]([F:26])[cH:25]1.[Na+:1].[Na+:2].[O-:3][C:4](=[O:5])[O-:6]>>[c:8]1(-[c:21]2[c:20]([F:19])[cH:25][c:24]([F:26])[cH:23][cH:22]2)[c:9]([C:10](=[O:11])[O:12][CH2:13][CH3:14])[cH:15][cH:16][cH:17][n:18]1

Participants

7

Reactant 6

HCID 702EthanolHCID 923Sodium ion2×HCID 1140TolueneHCID 19660Carbonate IonHCID 27343342,4-Difluorophenylboronic acidHCID 2796614Ethyl chloronicotinate

Product 1

HCID 21062877Ethyl 2-(2,4-difluorophenyl)pyridine-3-carboxylate

Sources & evidence

ORD record
ord-2db1767c977243c9b0fed6ee1b11c395
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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