HCID 58451205, compound → HCID 57930767, compound

Participants

Reaction Conditions

Reaction Steps

(E)-ethyl 3-(4-(cyclohexylamino)-2-(ethylamino)-6-methylpyrimidin-5-yl)acrylate (200 mg, 0.6 mmol) was dissolved in AcOH (2 mL). This solution was heated in a sealed tube at 186° C. for 17 h. Standard workup and purification by column chromatography gave 65 mg (38% yield) of 8-cyclohexyl-2-(ethylamino)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one.

Provenance & Evidence