Bromine → HCID 57930760, compound

HRID 1666284Notes

Reaction equation

HRID 1666284 reaction equation
[CH:1]1([N:7]2[C:12]3[N:13]=[C:14]([NH:18][CH2:19][CH3:20])[N:15]=[C:16]([CH3:17])[C:11]=3[CH:10]=[CH:9][C:8]2=[O:21])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:22]Br>CC(O)=O.C(Cl)Cl>[Br:22][C:9]1[C:8](=[O:21])[N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:12]2[N:13]=[C:14]([NH:18][CH2:19][CH3:20])[N:15]=[C:16]([CH3:17])[C:11]=2[CH:10]=1

Participants

5

Reactant 2

HCID 24408BromineHCID 57930767HCID 57930767, compound

Product 1

HCID 57930760HCID 57930760, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6344DichloromethaneSolvent

Procedure

To 8-cyclohexyl-2-(ethylamino)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one in AcOH and CH2Cl2 was added Br2 (22 uL, 0.42 mmol) at 80° C. Standard workup and purification by column chromatography gave 65 mg (0.17 mmol, 80% yield) of 6-bromo-8-cyclohexyl-2-(ethylamino)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one.

Workup

  1. customStandard workup and purification by column chromatography

Sources & evidence

ORD record
ord-ebde8fbedc5e408788d54acff7429db6
Source dataset
uspto-grants-2011_10
Patent number
US08044062B2

Reaction notes

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