HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-methyl-4-(3,4,5-trimethoxyphenyl)-8-isopropoxy-7-methoxy-1,4-dihydro-3(2H)-isoquinolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(3,4,5-trimethoxyphenyl)-2-acetoxy-N-methyl-N-(2-isopropoxy-3-methoxybenzyl)acetamide | HCID 67081869 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-methyl-4-(3,4,5-trimethoxyphenyl)-8-isopropoxy-7-methoxy-1,4-dihydro-3(2H)-isoquinolinone | HCID 67081819 | — |
Reaction Steps
A solution of the amide from step 2 above (6.2 g) in dichloromethane (60 ml) and trifluoroacetic acid (20 ml) was refluxed for 6 hours. The reaction mixture was concentrated to dryness and the residue was crystallized from methanol, giving 2-methyl-4-(3,4,5-trimethoxyphenyl)-8-isopropoxy-7-methoxy-1,4-dihydro-3(2H)-isoquinolinone (4.8 g), m.p. 128-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044067B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-10c6c26fdcac4290a295e8802e1c3c83 |
| Source note | uspto-grants-2011_10 |