HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Phenyl pyridazin-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | 4-Aminopyridazine | HCID 298492 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Phenyl pyridazin-4-ylcarbamate | HCID 14099147 | 37% |
Reaction Steps
A solution of 4-aminopyridazine (2.5 g, 26.3 mmol) in a mix of 1:1 THF:MeCN (20 mL), and pyridine (2.18, 27.6 mmol) was treated dropwise with phenylchloroformate (1.3 g, 27.6 mmol) in THF (10 mL). After stirring for 18 h, the resulting solid was collected and dried to provide the title compound (2 g, 37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044052B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-6ad89b72f0d74bcf843baccd558e9894 |
| Source note | uspto-grants-2011_10 |