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Pyridine → Phenyl (6-methoxypyridazin-3-yl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | 6-Methoxypyridazin-3-amine | HCID 81673 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Phenyl (6-methoxypyridazin-3-yl)carbamate | HCID 66833839 | 81.6% |
反応手順
A solution of 3-amino-6-methoxypyridazine (1.25 g, 10.0 mmol) in a mix of 1:1 THF:MeCN (20 mL), and pyridine (0.83 g, 1.5 mmol) was treated dropwise with phenylchloroformate (1.65 g, 10.5 mmol) in THF (10 mL). After stirring for 3 h, the resulting solid was collected and dried to provide the title compound (2 g, 81%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08044052B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-489b887e9d534f8dba87748a47bf6d47 |
| 出典メモ | uspto-grants-2011_10 |