HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-(4-(Trifluoromethyl)phenoxy)benzylidene)piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 86623904 | HCID 86623904 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-(4-(Trifluoromethyl)phenoxy)benzylidene)piperidine hydrochloride | HCID 66875732 | — |
Reaction Steps
tert-Butyl 4-(3-(4-(trifluoromethyl)phenoxy)benzylidene)piperidine-1-carboxylate (1.75 g, 4.0 mmol) from Step 4 was dissolved in CH2Cl2 (15 mL) and treated with HCl in dioxane (7.0 mL, 4.0 M, 28 mmol). After 16 h the reaction was concentrated in vacuo to provide the title compound as a white solid (1.49 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044052B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-6846325abc1045dc9f06324d7ed6e38f |
| Source note | uspto-grants-2011_10 |