反应详情

温度

150 °C

2-(3-(Chloromethyl)-5-ethoxyphenoxy)-5-(trifluoromethyl)pyridine from Step 3 was treated neat with triethylphosphite (0.30 mL, 1.75 mmol) and heated to 150° C. After 16 h, the reaction mixture was cooled and purified by silica gel chromatography (0-50%, EtOAc:CH2Cl2) to afford the title compound (400 mg, 82% yield) as a thick oil.

1. temperaturethe reaction mixture was cooled
2. custompurified by silica gel chromatography (0-50%, EtOAc:CH2Cl2)