反应详情

To a solution of tert-butyl 4-(4-chloro-3-(5-(trifluoromethyl)pyridin-2-yloxy)benzylidene)piperidine-1-carboxylate (280 mg, 0.597 mmol) in CH2Cl2 (3 mL) cooled to 0° C. was added TFA (0.46 mL, 5.97 mmol). The resulting mixture was stirred for 2 h at RT. The reaction was concentrated and then partitioned between saturated NaHCO3 solution and CH2Cl2. The organic extract was dried over Na2SO4, and concentrated under reduced pressure to give the title compound (250 mg).

1. concentrationThe reaction was concentrated
2. custompartitioned between saturated NaHCO3 solution and CH2Cl2
3. extractionThe organic extract
4. dry with materialwas dried over Na2SO4
5. concentrationconcentrated under reduced pressure