HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(3-(1-(Piperidin-4-ylidene)ethyl)phenoxy)-5-(trifluoromethyl)pyridine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(1-(3-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethylidene)piperidine-1-carboxylate | HCID 66876390 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3-(1-(Piperidin-4-ylidene)ethyl)phenoxy)-5-(trifluoromethyl)pyridine trifluoroacetate | HCID 86623912 | 97% |
Reaction Steps
To a solution of tert-butyl 4-(1-(3-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)ethylidene)piperidine-1-carboxylate (265 mg, 0.591 mmol) in CH2Cl2 (8 mL) was added TFA (2 mL). The reaction was stirred at RT overnight and concentrated to give an oil. This was redissolved in CH2Cl2 and concentrated to give the title compound as an oil (275 mg, 97% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044052B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-1d909165719d4395b59f88c576a1b974 |
| Source note | uspto-grants-2011_10 |