HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(3-(Phenyl(piperidin-4-ylidene)methyl)phenoxy)-5-(trifluoromethyl)pyridine trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(phenyl(3-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)methylene)piperidine-1-carboxylate | HCID 67445311 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3-(Phenyl(piperidin-4-ylidene)methyl)phenoxy)-5-(trifluoromethyl)pyridine trifluoroacetate | HCID 86623914 | 70% |
Reaction Steps
To a solution of tert-butyl 4-(phenyl(3-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)methylene)piperidine-1-carboxylate in CH2Cl2 (3 mL) was added trifluoroacetic acid (0.5 mL). The reaction was stirred overnight. The reaction was concentrated, redissolved in CH2Cl2 and concentrated again to give the title compound as an oil (33.7 mg, 70% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044052B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-4885579f4db146f69950e549ddf599bd |
| Source note | uspto-grants-2011_10 |