Thionyl Chloride → HCID 66876006, compound

Participants

Reaction Steps

[3-(4-Methyl-pyridin-2-yloxy)-phenyl]-methanol from Step 1 (4.75 g, 22.1 mmol), in dichloromethane (50 mL), was cooled to 0° C., and treated dropwise with thionyl chloride (1.93 mL, 26.5 mmol). The reaction mixture was allowed to warm to ambient temperature and was stirred for 3 h. Saturated aqueous sodium bicarbonate (20 mL) was added and the mixture was stirred at rt for 5 min. The organic layer was separated, dried over sodium sulfate, filtered and concentrated by evaporation to afford the desired product (5.16 g, 99% yield) as an oil.

Provenance & Evidence