反应详情

To a solution of tert-butyl 4-(3-(5-(pent-4-ynyloxy)pyridin-2-yloxy)benzylidene)piperidine-1-carboxylate (0.68 g, 1.33 mmol) in dry CH2Cl2 (3 mL) cooled to 0° C. was added TFA (1 mL, 13.3 mmol) dropwise. The mixture was stirred for 30 min. The reaction was concentrated and then partitioned between saturated NaHCO3 solution and CH2Cl2. The organic layer was dried over Na2SO4 and concentrated under reduced pressure to give the title compound (0.53 g, 99%). m/z (421.2, MH+).

1. concentrationThe reaction was concentrated
2. custompartitioned between saturated NaHCO3 solution and CH2Cl2
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated under reduced pressure