5-Bromo-2-chloropyrimidine → 5-Bromo-2-[(1-cyclopentylpiperidin-4-yl)oxy]pyrimidine

HRID 1666545Notes

Reaction equation

HRID 1666545 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[OH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH2:12][CH2:11]1>>[CH:16]1([N:13]2[CH2:12][CH2:11][CH:10]([O:9][C:2]3[N:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=3)[CH2:15][CH2:14]2)[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 217027851-Cyclopentylpiperidin-4-ol

Product 1

HCID 231159615-Bromo-2-[(1-cyclopentylpiperidin-4-yl)oxy]pyrimidine

Procedure

According to the same reaction process as in Example 1-1) but using 2-chloro-5-bromopyrimidine and 4-hydroxy-1-cyclopentylpiperidine, the entitled compound was obtained.

Workup

  1. customthe entitled compound was obtained

Sources & evidence

ORD record
ord-145a8dd1751d426ca8293eebf4b2ddf4
Source dataset
uspto-grants-2011_10
Patent number
US08044070B2

Reaction notes

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