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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666549Generated: October 29, 2026

HCID 23115973, compound → 2-(1-cyclopentylpiperidin-4-yloxy)-5-(1H-pyridin-2-on-5-yl)pyrimidine

https://huagongshe.com/reaction/1666549

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 23115973HCID 23115973—
ReactantHCID 178418361HCID 178418361—
CatalystHCID 178418390HCID 178418390—
SolventMethanolHCID 887—
Product2-(1-cyclopentylpiperidin-4-yloxy)-5-(1H-pyridin-2-on-5-yl)pyrimidineHCID 11371220—

Reaction Steps

10% palladium-carbon (700 mg) was added to a methanol solution (30 ml) of 2-(cyclopentylpiperidin-4-yloxy)-5-(2-benzyloxypyridin-5-yl)pyrimidine (2.22 g), and stirred in a hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered to remove palladium-carbon, and the filtrate was concentrated under reduced pressure to obtain the entitled compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08044070B2
Source datasetuspto-grants-2011_10
ORD IDord-433bfd3c7e3d4d498b07b44c9d173455
Source noteuspto-grants-2011_10