Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-Bromo-2-nitrotoluene | HCID 123546 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 59833399 | HCID 59833399 | — |
Reaction Steps
A mixture of 4-bromo-1-methyl-2-nitro-benzene (f-1) (0.01134 mol) and paraformaldehyde (0.009 mol) in DMSO (5 ml) and Triton-B (035 ml) was stirred at 50° C. for 2 hours, then cooled to room temperature and purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 98.5/1.5; 35-70 μm). The pure fractions were collected and the solvent was evaporated. Yield: 1.18 g of 2-(4-Bromo-2-nitro-phenyl)-ethanol (f-2) (42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08044073B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-0b6666a17a9d4588904401163db0c4b7 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
