1,2-Dichloroethane → HCID 67444739, compound

Participants

Reaction Steps

To 3-chloro-5-[(ethylamino)sulfonyl]-2-fluorobenzoic acid (60 mg, 0.213 mmol) in DMF (3 ml) and DCM (3 ml) was added EDC (40.8 mg, 0.213 mmol) and HOBt (32.6 mg, 0.213 mmol). After 10 mins, 5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-amine (46.7 mg) was added. The reaction mixture was stirred at rt overnight, concentrated and purifed by HPLC to give the title compound (14 mg), C/MS: m/z 421.0 (M+H), Rt 1.91 min.

Provenance & Evidence