HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1666579Generated: November 2, 2026
Trifluoroacetic acid → HCID 59591391, compound
https://huagongshe.com/reaction/1666579
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Thiosemicarbazide | HCID 2723789 | — |
| Reactant | 1-[3-(Trifluoromethyl)phenyl]cyclobutane-1-carbonitrile | HCID 22406710 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59591391 | HCID 59591391 | — |
Reaction Steps
To a T-vial containing 1-[3-(trifluoromethyl)phenyl]cyclobutanecarbonitrile (1 eq) and hydrazinecarbothioamide (1 eq) was added TFA (1 eq) dropwise at rt. Then the mixture was heated to 60° C. for 2 hrs and cooled to rt. Ethyl acetate and aq. NaHCO3 were added and extracted with ethyl acetate twice, the organic layers combined, dried with MgSO4, and concentrated to give the desired product which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08044075B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-0b021ed8501a4e6e92a1af5e62742977 |
|---|
| Source note | uspto-grants-2011_10 |
|---|
