3-Hydroxy-4-methylbenzoic acid → 4-Methyl-3-(1-methylethoxy)benzoic acid

HRID 1666581Notes

Reaction equation

HRID 1666581 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8](C(O)=O)=[CH:7][C:6]=1[CH3:14])([CH3:3])[CH3:2].OC1C=C(C=CC=1C)[C:19]([OH:21])=[O:20]>>[CH:1]([O:4][C:5]1[CH:13]=[C:12]([CH:8]=[CH:7][C:6]=1[CH3:14])[C:19]([OH:21])=[O:20])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 685123-Hydroxy-4-methylbenzoic acidHCID 592729354-Isopropoxy-3-methylbenzoic acid

Product 1

HCID 207105234-Methyl-3-(1-methylethoxy)benzoic acid

Procedure

3-Isopropoxy-4-methyl-benzoic acid (1.70 g) is prepared in analogy to 4-isopropoxy-3-methyl-benzoic acid starting from 3-hydroxy-4-methyl-benzoic acid (2.00 g); LC-MS: tR=0.91 min.

Sources & evidence

ORD record
ord-bbc469bf28bc4ba48e76e4137f9f0ae7
Source dataset
uspto-grants-2011_10
Patent number
US08044076B2

Reaction notes

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