Epichlorohydrin → HCID 86640706, compound

Participants

Reaction Steps

A mixture of 4-[5-(4-isopropoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenol (370 mg, 1.14 mmol) and epichlorohydrine (317 mg, 3.42 mmol) in isopropanol (5 mL) and 3 N aq. NaOH (1.5 mL) is stirred at rt for 16 h. The mixture is diluted with EA, washed with water, dried over MgSO4, filtered and concentrated. The crude product is purified by chromatography on prep. TLC plates with heptane:EA 3:1 to give 3-(3,5-dimethyl-4-oxiranylmethoxy-phenyl)-5-(4-isopropoxy-phenyl)-[1,2,4]oxadiazole (256 mg) as white solid; LC-MS: tR=1.14 min, [M+1]+=381.18.

Provenance & Evidence