反应详情

温度

130 °C

A mixture of 2-chloro-4-cyclohexylquinazoline (0.25 g), 1-((S)-3-aminopyrrolidin-1-yl)-2-(4-trifluoromethoxyphenyl)ethanone mono hydrochloride (0.49 g), N,N-diisopropylethylamine (0.52 mL), N-methylpyrrolidone (1.0 mL), and n-butanol (1.0 mL) was stirred at 130° C. for 24 h. To the reaction mixture was added saturated aqueous sodium hydrogencarbonate, and the mixture was extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, the desiccant was removed by filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (NH silica gel, ethyl acetate) to obtain the title compound (0.21 g).

1. extractionthe mixture was extracted with chloroform
2. dry with materialThe organic layer was dried with anhydrous sodium sulfate
3. customthe desiccant was removed by filtration
4. concentrationthe filtrate was concentrated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (NH silica gel, ethyl acetate)