Isopropanol → HCID 57970196, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-biphenyl-2-yl-1-((S)-3-(4-chloroquinolin-2-ylamino)pyrrolidin-1-yl)ethanone (0.43 g), 1-(t-butoxycarbonyl)piperazine (0.18 g), triethylamine (0.17 g), and isopropanol (1.3 mL) was heated at 180° C. in a microwave reaction apparatus for 5 h. The reaction mixture was diluted with chloroform and water, and then the aqueous layer was extracted with chloroform and dried with anhydrous magnesium sulfate. The desiccant was removed by filtration, then the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/a solution of 2 M ammonia in methanol=9:1) and then solidified in diethyl ether to obtain the title compound (22 mg).

Provenance & Evidence