Urea → HCID 178518335, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-4-fluorobenzoic acid (25.3 g) and urea (48.9 g) was gradually added to a flask heated at 160° C. and then heated to 245° C. over 30 min. Light yellow solids were precipitated. The reaction mixture was cooled to room temperature, then methanol (250 mL) was added to the reaction mixture, the mixture was heated to reflux for 30 min, the solids were washed and cooled to room temperature, and then the precipitated solids were collected by filtration. The resulting solids were washed again with methanol (300 mL) to obtain 7-fluoroquinazoline-2,4-diol (26.3 g).

Provenance & Evidence