HCID 57970179, compound → HCID 57970081, compound

Participants

Reaction Conditions

Reaction Steps

t-Butyl 4-(2-((S)-1-benzylpyrrolidin-3-ylamino)quinazolin-4-yl)piperazine-1-carboxylate (26 g) was dissolved in methanol (260 mL), followed by addition of 20% Pd(OH)2/C (5.2 g), and the mixture was stirred under hydrogen atmosphere at room temperature for 16 h and at 50° C. for 8 h. 20% Pd(OH)2/C (5.2 g) was further added, and the mixture was stirred under hydrogen atmosphere for 3 days. The catalyst was removed by filtration, then the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/a solution of 1 M ammonium in methanol=9:1) to obtain the title compound (6.3 g).

Provenance & Evidence