HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Trans-benzyl (4-hydroxypyrrolidin-3-yl)carbamate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | trans-Tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-hydroxypyrrolidine-1-carboxylate | HCID 57970124 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Trans-benzyl (4-hydroxypyrrolidin-3-yl)carbamate hydrochloride | HCID 86636483 | — |
Reaction Steps
t-Butyl (3R,4R)-3-benzyloxycarbonylamino-4-hydroxypyrrolidine-1-carboxylate (16 g) was dissolved in chloroform (143 mL), followed by addition of a solution (72 mL) of 4 M HCl in 1,4-dioxane, and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure to obtain benzyl ((3R,4R)-4-hydroxypyrrolidin-3-yl)carbamate mono hydrochloride. This compound was used in the subsequent step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044068B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d7852294bded495e9a899ac71aebfd5c |
| Source note | uspto-grants-2011_10 |