Potassium tert-butoxide → HCID 178436964, compound

HRID 1666681Notes

Reaction equation

HRID 1666681 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[NH:11][C:12](=[O:24])[CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])(=O)[CH2:2][CH3:3].CC(C)([O-])C.[K+]>C(O)C>[CH2:2]([C:1]1[C:5]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:11]=[C:12]([OH:24])[C:13]=1[C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[CH3:3]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 57970073Phenylmethyl 3-oxo-3-[[2-(1-oxopropyl)phenyl]amino]propanoate

Product 1

HCID 178436964HCID 178436964, compoundYield 82.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Benzyl N-(2-propionylphenyl)malonamate (1.8 g) was dissolved in ethanol (20 mL), followed by addition of potassium t-butoxide (0.65 g), and the mixture was stirred at room temperature for 3 h. The precipitated solids were collected by filtration and washed with water to obtain benzyl 4-ethyl-2-hydroxyquinoline-3-carboxylate (1.4 g).

Workup

  1. filtrationThe precipitated solids were collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-c5d2b29600a243548972eb3904b7e73e
Source dataset
uspto-grants-2011_10
Patent number
US08044068B2

Reaction notes

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