HCID 178436964, compound → HCID 178436969, compound

Participants

Reaction Conditions

Reaction Steps

Benzyl 4-ethyl-2-hydroxyquinoline-3-carboxylate (1.2 g) was suspended in methanol (12 mL) and THF (6 mL), followed by addition of 5% Pd—C (120 mg), and the mixture was stirred at 40° C. for 1 day. The catalyst was removed by filtration, and then the filtrate was concentrated under reduced pressure to obtain 4-ethyl-2-hydroxyquinoline-3-carboxylic acid (0.85 g). This compound was used in the subsequent step without purification.

Provenance & Evidence