HCID 67443331, compound → HCID 67443063, compound

HRID 1666690Notes

Reaction equation

HRID 1666690 reaction equation
[F:1][CH:2]1[CH:6]([NH:7][C:8]2[N:13]=[C:12]([CH3:14])[CH:11]=[C:10]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[N:9]=2)[CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[CH2:3]1>CO.[Pd]>[F:1][CH:2]1[CH2:3][NH:4][CH2:5][CH:6]1[NH:7][C:8]1[N:13]=[C:12]([CH3:14])[CH:11]=[C:10]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)[N:9]=1

Participants

4

Reactant 1

HCID 67443331HCID 67443331, compound

Product 1

HCID 67443063HCID 67443063, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl (3RS,4RS)-3-fluoro-4-(4-methyl-6-morpholin-4-ylpyrimidin-2-ylamino)pyrrolidine-1-carboxylate (20 mg) was dissolved in methanol (1 mL), followed by addition of 5% Pd—C (40 mg), and the mixture was stirred under hydrogen atmosphere for 6 h. The catalyst was removed by filtration, and then the filtrate was concentrated under reduced pressure to obtain ((3RS,4RS)-4-fluoropyrrolidin-3-yl)-(4-methyl-6-morpholin-4-ylpyrimidin-2-yl)amine (13 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-95c19b715dde47bfbfc7132b214bf3e3
Source dataset
uspto-grants-2011_10
Patent number
US08044068B2

Reaction notes

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