Bactroban → Mupirocin Calcium

Participants

Reaction Conditions

Reaction Steps

Amorphous mupirocin calcium (14 g) was dissolved in water (35 ml) and stirred for one hour. The mixture was cooled to 5° C. and kept at this temperature for 15 hours. Then mixture was then stirred at 5° C. for 3 hours. The crystalline product was filtered and dried in an air circulated oven at room temperature. Mupirocin calcium dihydrate (12.5 g, 83%) was obtained.

Provenance & Evidence