反应详情

温度

40 °C

To the suspension of 0.55 g (4 mmol) methy 3-amino-2-methylpropionate hydrogen chloride salt and 4 ml chloroform 0.52 g (5.2 mmol) triethylamine and 0.3 g (2 mmol) 2-chloro-1,3-benzoxazole are added and the mixture is stirred at 40° C. for 4 hours and at room temperature for 12 hours. The chloroform solution is washed with water, citric acid solution and water, dried over sodium sulfate and evaporated in vacuum. The residue is treated with hexane, the crystals are filtered off and washed. 0.33 g title compound is obtained as white crystals. Mp: 89-90° C.

1. additionare added
2. washThe chloroform solution is washed with water, citric acid solution and water
3. dry with materialdried over sodium sulfate
4. customevaporated in vacuum
5. additionThe residue is treated with hexane
6. filtrationthe crystals are filtered off
7. washwashed