Oxalic Acid → HCID 21071558, compound

Participants

Reaction Steps

Add dropwise oxalic acid (1.32 g, 1.3 eq.) in MeOH to a solution of 4-chlorotryptamine in EtOAc (2.2 g, 11.3 mmol) with vigorous stirring. When addition was complete, add Et2O to the cloud point and place flask in the freezer to give a solid. Collect the solid by filtration and wash with ether. Dry in a vacuum oven at room temperature to give the title compound as an off-white solid: 1H NMR (300 MHz, d6-DMSO): 3.11 (m, 2H), 3.2 (m, 2H), 7.04 (m, 2H), 7.34 (m, 2H), 11.44 (bs, 1H); MS (ES+): m/z 195 (M+H)+, 178 (M−NH2)+; (ES−): m/z 193 (M−H)−; Analysis for C12H13ClN2O4: Calcd.: C, 50.6263; H, 4.6026; N, 9.8396. found: C, 50.56; H, 4.57; N, 9.66.

Provenance & Evidence