Hydrochloric Acid → HCID 21071629, compound

Participants

Reaction Steps

Combine N-(2-(5-methoxycarbonyl-1H-indol-3-yl)ethyl)-3-(2,2,2-trifluoroethoxy)benzylamine (200 mg, 0.5 mmol) in 50 mL THF and 1 mL 3 N NaOH. Reflux the mixture overnight, treat with 0.7 mL 5 N HCl and concentrate to dryness. Chromatograph to give the title compound: ISMS 393 (M+1); Analysis for C20H19F3N2O3 CF3COOH 1.2C7H8 2.1H2O: calcd: C, 55.76; H, 5.20; N, 4.28. found: C, 55.51; H, 5.47; N, 4.50.

Provenance & Evidence