4-Toluenesulfonyl chloride → 2,2,3,3,3-Pentafluoropropyl p-Toluenesulfonate

Participants

Reaction Steps

Combine 2,2,3,3,3-pentafluoropropan-1-ol (9.7 ml) and pyridine. Cool to between 0° C. and 10° C. and add portion-wise the p-toluenesulfonylchloride (6.2 g) and stir with warming to room temperature. After 3 hours at room temperature, pour the reaction mixture into ice water and stir for 30 min to give a solid. Filter the solid, wash with water, and dry to give of the title compound.

Provenance & Evidence