4-Toluenesulfonyl chloride → 3,3,3-Trifluoroprop-1-yl toluene-4-sulphonate

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Reaction Steps

Add 3,3,3-trifluoropropan-1-ol (618 ml) and pyridine (224 ml). Cool to between 0° C. and 10° C. and add portion-wise p-toluenesulfonylchloride (147 g). Allow to warm to ambient temperature and stir overnight. Add HCl 0.5N (1.6 L), extract with ethyl acetate, combine the organic layers, dry over MgSO4, filter, and evaporate to give the title compound.

Provenance & Evidence