Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylpiperazine → Olanzapine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile | HCID 67445262 | — |
| 생성물 | Olanzapine | HCID 135398745 | — |
반응 단계
The process disclosed herein comprises reaction of 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile [10] with N-methylpiperazine in conjunction with N-methyl piperazine acid salt to give Olanzapine. The reaction is carried out at 90-138° C., preferably at 110-125° C. in 6-12 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08044196B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-5e13e6863e2544d6bf3dbc3514595fe8 |
| 출처 메모 | uspto-grants-2011_10 |