Benzene, (3-bromopropoxy)- → Aclidinium Bromide

Participants

Reaction Steps

The moles of 2-hydroxy-2,2-dithien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)yl ester indicated in column B were suspended in the amount (column E) of the solvent indicated in column D. Then, the amount of 3-phenoxypropyl bromide resulting from multiplying column B by column C was added to the resulting suspension and the mixture was stirred for 6 h at reflux in an inert atmosphere. The solvents were subsequently evaporated to yield 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide. The product was isolated by filtration at room temperature and both the yield and the level of 3-phenoxypropyl bromide were determined and indicated in columns F and G, respectively.

Provenance & Evidence