HCID 522663, compound → HCID 45275805, compound

Participants

Reaction Steps

A solution of N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (0.060 g, 0.313 mmol), 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid (Example 1C, 0.059 g, 0.198 mmol) and 2,2-diphenylmorpholine (0.050 g, 0.209 mmol, CAS 77373-34-3) in dichloromethane (0.5 mL) was stirred at room temperature. After stirring overnight, the reaction was loaded directly onto a SF15-12 silica gel column (Analogix®, Burlington, Wis.), and the title compound was eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (flow=30 mL/minute). 1H NMR (300 MHz, CDCl3) δ ppm 7.43 (s, 20H), 4.15 (s, 2H), 4.09 (s, 2H), 3.39-3.44 (m, 2H), 3.28-3.33 (m, 2H), 3.27 (t, J=6.4 Hz, 2H), 2.57 (t, J=6.6 Hz, 2H); MS (ESI+) m/z 517 (M+H)+.

Provenance & Evidence