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HRID 1667112作成日:2026年10月25日

(4aS,7aS)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate → (4aS,7aS)-tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

https://huagongshe.com/reaction/1667112

反応式

関与物質

役割名称HCID仕込み量
反応物(4aS,7aS)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylateHCID 29973012—
触媒Palladium hydroxideHCID 9942167—
溶媒MethanolHCID 887—
生成物(4aS,7aS)-tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylateHCID 1519435—

反応手順

The product from Example 50A (0.15 g, 0.5 mmol) in methanol (80 mL) was hydrogenated (4 pounds per square inch) in the presence of palladium hydroxide on carbon (0.42 g) for 3 hours at room temperature. The reaction mixture was filtered and concentrated to yield the title compound. MS (DCI) m/z 227 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08044069B2
出典データセットuspto-grants-2011_10
ORD IDord-362870eaaf9c4d0dbb32ddfa06744e6a
出典メモuspto-grants-2011_10